The purpose of this study is to evaluate the effects of low-frequency repetitive transcranial magnetic stimulation on anxiety state in older patients with generalized anxiety disorder.
Inclusion Criteria
- 1）Age≥60 years, regardless of gender.
- 2）Meets the diagnostic criteria for generalized anxiety disorder in the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V) developed by the American Psychiatric Association.
- 3）HAMA score≥14 and HAMD-17 items score \<17.
- 4）No adjustment in the type and dose of anti-anxiety medication in the 3 months prior to randomization.
- 5）Willing to participate and sign the informed consent.
Exclusion Criteria
- 1）Traumatic brain injury or other conditions affecting the brain, such encephalitis, brain tumors, or intracranial hypertension.
- 2）Previous history of epilepsy, family history of epilepsy or presence of seizure provoking factors or alcohol abuse.
- 3）History of other psychiatric disorders such as current post-traumatic stress disorder, substance use disorder (within 6 months), bipolar disorder and obsessive-compulsive disorder.
- 4）Unstable mental state with impulses toward self-harm or suicide.
- 5）Presence of intracranial metal implant, cochlear implant, built-in pulse generator (such as cardiac pacemaker), etc.
- 6）Medical or surgical disorders that are severe or unstable.
- 7）Pregnancy or breastfeeding.
- 8\) Those who are participating in other clinical research or has participated in other clinical research or has participated in this study within 3 months prior to enrollment.
- 9\) Other conditions that the researchers think are not suitable for the project.