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Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time

Los Angeles, California (+1 more) · Ages 18–65 · Therapy / behavioral · NCT06705179

This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses with a longitudinal approach over a 12 month interval. Participants will be healthy participants recruited through Prolific an on-line crowdsourcing service, and psychiatric patients and healthy participants recruited via UCLA Psychiatry Clinics and UCLA's STAND Program

Inclusion criteria (healthy control participants):

  • Age range of 18 to 65.
  • Not currently having a psychiatric diagnosis determined after psychiatric evaluation by Drs. Tadayon-Nejad and Wei (both are board certified psychiatrists).
  • Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.
  • Ability to give informed consent.

Exclusion criteria (healthy control participants):

  • Prior history and or current diagnosis of neurological disease.

Inclusion criteria (patients):

  • Age range of 18 to 65.
  • Psychiatric diagnosis of any type of depressive disorders, any type of anxiety disorders or obsessive-compulsive disorder.
  • Primary or comorbid bipolar disorders are allowed but only if not in the acute manic phase.
  • Comorbidity with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are allowed.
  • Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks.
  • Ability to give informed consent.

Exclusion criteria (patients):

  • Prior history and or current diagnosis of neurological disease.
  • History or current diagnosis of psychotic disorders.
  • Currently active substance use disorder.

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This page is for general information only and is not a guarantee of eligibility or enrollment. Trial details are subject to change — the study site will confirm final eligibility criteria.